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from the injections menu
MUSE FAQ
The following is from a leaflet produced by the UK division of the American Foundation for Urologic Diseases (AFUD).
Developed in the United States of America, MUSE is the latest addition to the treatments available for erectile dysfunction (impotence). This fact sheet provides basic information on MUSE; for more detailed information you should consult your doctor.
 What is MUSE?
What medication is used in MUSE?
What is involved in this form of treatment?
How soon after using MUSE does erection occur?
How long will the erection last?
What side effects may be associated with MUSE?
Are there any side effects in the female partner?
What conditions may prevent a man using MUSE?
How can I obtain MUSE?
What is MUSE?
MUSE is short for "medicated urethral system for erection." This treatment is based on the discovery that the urethra (the tube passing from the bladder to the tip of the penis through which urine is passed and semen ejaculated) can absorb certain medications, which can then pass into the surrounding erectile tissue creating an erection.
What medication is used in MUSE?
The active ingredient in MUSE is alprostadil. This is identical to a naturally occurring substance within the penis which is involved in the development of an erection. Alprostadil has been used in the treatment of impotence for many years. Before the introduction of MUSE it had to be injected into the penis when an erection was wanted. Alprostadil relaxes the muscles in the erectile tissue of the penis allowing increased blood flow, the basis of a normal erection.
What is involved in this form of treatment?
In MUSE, alprostadil is formulated as a small pellet which is supplied in a specially designed applicator. Each MUSE applicator is individually foil wrapped. The applicator has a narrow stem which can be introduced easily into the urethra. After inserting the applicator, the alprostadil pellet is then released into the urethra by depressing a button on the top of the applicator.
The manufacturer recommends that immediately prior to insertion of MUSE, the man urinates and then gently shakes the penis several times to remove excess urine. A moist urethra makes administration of MUSE easier and facilitates the absorption of alprostadil.
How soon after using MUSE does erection occur?
An erection usually occurs within five to ten minutes of administration.
How long will the erection last?
When this form of treatment is effective, an erection generally lasts 30 to 60 minutes. Extremely rarely a prolonged erection may occur. MUSE can be used twice in any 24 hour period, however 2 units should not be used consecutively.
Different doses: MUSE is available in four strengths - 125 mcg, 250 mcg, 500 mcg and 1,000 mcg. The initial dose is selected by the doctor.
What side effects may be associated with MUSE?
Side effects have been reported only infrequently. When first using MUSE, some men experience minor discomfort from insertion but prior urination will reduce the chance of this happening.
Following the first dose of MUSE, fainting has occurred, but only in an extremely small proportion of men. However, for this reason, it is recommended that the first dose of MUSE should be in the doctor's office.
Other side effects that have been reported, albeit extremely rarely, include
light-headedness, dizziness, fainting, rapid pulse and swelling of the leg veins. Patients are advised not to drive up to one hour after using MUSE.
Are there any side effects in the female partner?
Mild vaginal itching and burning have been reported.
What conditions may prevent a man using MUSE?
MUSE should not be used in the following conditions:
Known hypersensitivity (allergy) to alprostadil
An abnormally formed penis
Diseases that might result in prolonged erection (e.g. sickle cell anemia or trait, leukemia, multiple myeloma).
MUSE should not be used for sexual intercourse with a pregnant woman unless a condom is used.
How can I obtain MUSE?
MUSE is available only on prescription. You should discuss this form of treatment with your doctor who may prescribe it for you or refer you to a specialist clinic.
The Web site of MUSE can be accessed via another page.
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| This information is provided for educational purposes only and does not replace or amend professional medical advice. Unless otherwise stated and credited, the content of Phoenix5 (P5) is by and the opinion of and copyright © 2000 Robert Vaughn Young. All Rights Reserved. P5 is at <http://www.phoenix5.org>. P5's policy regarding privacy and right to reprint are at <www.phoenix5.org/infopolicy>.
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