||Pros and Cons
||Relaxes smooth muscle in corpora
||Taken 1 hour before sex, requires stimulation
||Headache, diarrhea, flushing, hypotension, disturbed color vision.
Greatest help with partial ED
In final trials
|CNS stimulant that triggers erections (dopa-minergic)
||Works in up to one-third of mild cases
Under FDA review
|Alpha-adrenergic antagonist relaxes smooth muscle and increases blood
||Taken 2040 minutes before sex. Helps 6080% of those tested.
Fewer side effects than sildenafil.
|Applicator inserted into urethra
||Applied 510 minutes before sex. Erection lasts 1 hour
||Can be used 2 times/day.
Not for use with pregnant partner.
|Injected into corpus cavernosa. Relaxes smooth muscle and dilates blood
||Injected 20 minutes before sex. Lasts >1 hour. Effective >50%.
||May be very painful.
Cannot be used every day.
||Different formulation alprostadil
||Injected with smaller needle. Injected 10 minutes to 2 hours before sex.
Erections last >1 hour.
||Cheaper than Caverject.
|Invicorp (VIP and phentolamine).
FDA submission 1998
|Relaxes smooth muscle
||Just before sex. More effective than either agent above.
|Draws blood into corpora by negative pressure
||Just before sex.
Erections last until elastic ring removed
|Clumsy. Interferes with foreplay. Difficult ejaculation.
|Rigid or malleable rod or inflatable
||Bent or pumped into erect state
||Destroys erectile tissue. Complications high in diabetes.
|(from "Erectile Dysfunction in Diabetes:
Pills for Penile Failure" in Clinical Diabetes journal, 1998, No. 3). Go to the resources page for the URL of the journal. |